Tumors Derived from PROCR-positive Mammary Stem Cells Give Rise to Claudin-Low Breast Cancer with Poor Prognosis
Date:
Contribution at the Computational Systems Biology of Cancer meeting at Institut Curie which won the “best talk” prize.
In the talk, I mostly focused on how we extract molecular fingerprints from the derived tumors using non-negative matrix factorization (NMF). Subsequently, we project triple-negative breast cancer patients’ samples from TCGA and Metabric on the latent space and divide them by the exposure to the Procr-metagene. We show that patients with high exposure have reduced survival.